I hold that negative feedback is a philosophical principle of anything sexual. I assume that it is a philosophical principle because of its overriding, all-encompassing presence. It is equally present in the realm of sexual physiology and sexual psychology, in the material and the ideological world.

"Negative feedback", in this case, has nothing to do with critical email I receive on my articles. "Negative feedback" means that any sexual stimulus loses its power the more often or the longer it is experienced or applied.

In the realm of psychology, everybody, sooner or later, gets bored with one and the same sexual partner all over again.

In the realm of endocrine physiology, any pro-sexual hormonal spike is followed by a hypothalamic impulse to down-regulate precisely this spike.

And in the realm of pharmacological libido enhancement, dopaminergic drugs noticeably decline in effectiveness after a number of applications.

It's our destiny as sexually defined life forms to constantly be on the search for the new thrill. And the more successful we are in colonizing new territory, the more we need to expand. You can't beat the system. We are EVER only satisfied for the moment, but in reality, we NEVER have enough.

There is no best woman. If we are married to a beauty queen, and if the only other woman we see in our palace is rather ordinary (though not ugly), then, sooner or later, the non-consumed other, ordinary woman will exert as much sexual attraction as the daily consumed beauty queen. This may only be momentary, but this is enough to teach men that sexual attraction is a function of newness as much as of beauty.

Yes, this can be expressed mathematically, as a formula with a number of variables enclosed in parentheses, and with integrals and sinus curves expressed in plain numbers. Sexual enhancement is a serious science.

And a new form of art.

Ever on the lookout for a new pharmacological twist that allows me to recreate the sexual experience from a new angle, I have tried more drugs and drug combinations (for the sole assessment of how they impact on libido and orgasm) than anybody I know.

But I am caught in a treadmill. The further I run, the more I stay at one place.

No woman ever satisfies me terminally. And there is no drug that creates an endless bliss. Negative feedback, psychologically and pharmacologically, always assures that after every step forward, I am back on baseline.

But don't get me wrong. This is no exercise in futility. Like the man in the treadmill, I'm on a runners' high.

While every new girlfriend is bound to ride a downward curve, and while dose increases of dopaminergics only go so far, it is my constant aim to keep the roller coaster fuelled.